Coronary angiography is considered the gold standard for the assessment of coronary artery disease. Cardiologists perform millions of coronary angiograms annually worldwide. Angiography is a 2-dimensional lumenogram of a complex 3-dimensional arterial structure; therefore, it is limited in providing accurate diagnostic information. An angiogram using multiple orthogonal views with visual estimation can provide information about a patient’s coronary artery anatomy; however, this approach has several limitations due to inherent operator variability, which can lead to wide differences in interpretation of stenosis severity obtained from angiography in comparison to non-invasive imaging, expert core lab assessment, computer assisted measurements, and autopsy comparisons.